SWASAMRUTHAM COUGH SYRUP

 ‘To Ease The Difficult Breathing’

An Ayurvedic Proprietary Medicine of Vaidyaratnam Oushadasala, Swasamrutham Cough Syrup designed and developed by R&D Department.

Ingredients:

Each 10 ml prepared out of :

Cumulative pharmacological properties of the formulation

Rasa   :Tikta, Kasaya, Katu

Virya  :Usna

Vipaka:Katu

Guna   :Laghu, Ruksha

Cumulative pharmacological actions of the formulation

Tridosasamaka especially Kaphavatasamaka, Swasahara, Kasahara, Swarya, Kantya, Hikka nigraha, Sothahara, Ruchya, Swarya Deepana, Pachana, Agnivardhaka, Hridya, Ruchya, Rujahara, Vranahara,

Indications: 

Breathlessness, Cough, Bronchitis

Dosage: 

Adults: 15ml two to four times daily, or as directed by the Physician.

Children: 5 ml two to four times daily, or as directed by the Physician.

Supportive phytochemicals:

Vasicine, Vasicinone, tannins, lignans, iridoid glycosides, Arabinose, triterpenoids, Mannitol, quercetin, lapachol, Calcium, Sodium, chrysin, Luteolin, baicalin, L-arginine, lysine, palmitic acid, lauric acid, stigmasterol, Hordenine, Genistein, Amino Acids, fatty acids, harmaline, Rutin, Astragalin, Diosgenin, Glycosides, chlorogenic acid, Phellandrene, Luteolin, palmitic acid, D-limonene, cadinene, carotene, Orientin, Ursolic acid, Riboflavin,

• Adhatoda vasica - Vasicine have bronchodilatory, respiratory stimulant.[1]
• Ocimum sanctum – Eugenol ugenol treatment reduce lung inflammation and improving lung function.[2]
• Aegle marmelos  - Cineole is effective in treating acute bronchitis, which can be explained by its proven pharmacodynamics and pharmacological properties. In other clinical studies the anti-inflammatory and also mucolytic effects could be proven in patients with Rhinosinusitis, COPD and Asthma.Expectorant [3]
• Gmelina arborea - Luteolin alleviates inflammation and oxidative stress in chronic obstructive pulmonary disease[4]
• Premna corymbosa – Betulin have antibacterial anti-inflammatory properties.[5]
• Stereospermum colais –Luteolin anti-inflammatory.[6]
• Oroxylum indicum - oroxylin have anti-allergic effects. It can reduce inflammatory signs and mucin production in lungs and beneficial effects on allergic asthma.[7]
• Solanum melongena - Tropane alkaloids are anti-secretory anti-spasmodic, antiemetic in action and are being used for treating allergies, asthma and chronic obstructive pulmonary disease (COPD).[8]
• Aerva lanata – Quercetin, an antioxidant flavonoid has been shown to exert strong anti-viral activities when cultured with target cells and causal agents of URTI such as severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and several adenoviruses.[9]
• Desmodium gangeticum - The flavonoids such as gangetin, desmocarpin and desmodin isolated from the species Desmodium gangeticum are responsible for antioxidant and immunomodulatory activities.[10]
• Pseudarthria viscida - oleic acid has beneficial effect on nflammatory diseases.[11]
• Tribulus terrestris- Terrestrosin D exhibits anti-tumour and anti-inflammatory activities.[12]
• Cinnamomum camphora - 1,8-cineole, is a natural monoterpene, also known as eucalyptol, It is known for its mucolytic and spasmolytic action on the respiratory tract. It also shown therapeutic benefits in inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD).[13]
• Trachyspermum roxburghianum – sabinene have antioxidant, antimicrobial, analgesic, and wound healing activities.[14]
• Mentha arvensis – Menthol acts as a potent broad-based counterirritant in respiratory system.[15]

Cumulative Pharmacological Action:

Anti-inflammatory, Bronchodilator, Expectorant, Tonic, Antioxidant, Antispasmodic.

Reference

[1] V Duraipandiyan 1,2,*, N A Al-Dhabi 1, C Balachandran 2, S Ignacimuthu 1,2,3, C Sankar 2, K Balakrishna 2, Antimicrobial, Antioxidant, and Cytotoxic Properties of Vasicine Acetate Synthesized from Vasicine Isolated from Adhatoda vasica L., PubMed, 2015 Jan 14;2015:727304.doi:10.1155/2015/727304

[2] Clarissa B Magalhães 1, Douglas R Riva, Leonardo J DePaula, Aline Brando-Lima, Vera Lúcia G Koatz, José Henrique Leal-Cardoso, Walter A Zin, Débora S Faffe, In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury, PubMed, 2010 Apr;108(4):845-51.doi: 10.1152/japplphysiol.00560.2009. 

[3] Juergen Fischer 1,, Uwe Dethlefsen 2, Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial , PubMed, 2013 Nov 21;9:25. doi: 10.1186/1745-9974-9-25,

S Monika 1, M Thirumal 1,*, PR Kumar 1 Phytochemical and biological review of Aegle marmelos Linn, PubMed, 2023 Mar 23;9(3):FSO849. doi: 10.2144/fsoa-2022-0068

[4] Mingfei Li 1, Huifang Wang 1, Yun Lu 1, Jinwen Cai  Luteolin suppresses inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibition of the NOX4‐mediated NF‐κB signaling pathway, PubMed, 2023 Apr 27;11(4):e820. doi: 10.1002/iid3.820

[5] Betulin Wojciech Szlasa 1,✉, Sylwester Ślusarczyk 2, Izabela Nawrot-Hadzik 2, Renata Abel 2,3, Aleksandra Zalesińska 1, Anna Szewczyk 4, Natalia Sauer 5, Robert Preissner 6, Jolanta Saczko 4, Marcin Drąg 7, Marcin Poręba 7, Małgorzata Daczewska 8, Julita Kulbacka 4,✉, Małgorzata Drąg-Zalesińska 9 Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages, PubMed, 2022 Oct 25;46(2):573–583. doi: 10.1007/s10753-022-01756-4

[6] G Odontuya 1, J R S Hoult, P J Houghton, Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides, PubMed, 2005 Sep;19(9):782-6. doi: 10.1002/ptr.1723.

[7]Ae-Yeon Lee 1, Saeromi Kang 1, Soo-Jin Park 1, Jin Huang 1, Dong-Soon Im 1 Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments, PubMed,  2016 May 1;24(3):283-90.doi: 10.4062/biomolther.2016.071.

[8] Kyu Hwan Shim 1, Min Ju Kang 2, Niti Sharma 1,✉, Seong Soo A An 1, Beauty of the beast: anticholinergic tropane alkaloids in therapeutics, PubMed,  2022 Sep 16;12(1):33. doi: 10.1007/s13659-022-00357-w

[9] Serena A Heinz a, Dru A Henson a, Melanie D Austin b, Fuxia Jin b, David C Nieman b Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial, PubMed, 2010 May 15;62(3):237–242. doi: 10.1016/j.phrs.2010.05.001

 [10] Vedpal Singh 1, Rohit Singh 2, Manish Pal Singh 3, Archita Katrolia 4, Therapeutic Role of Desmodium Species on its Isolated Flavonoids, PubMed, 2024;24(1):74-84. doi: 10.2174 /1566524023666221213111851.

[11] Helioswilton Sales-Campos 1, Patricía Reis de Souza, Bethânea Crema Peghini, João Santana da Silva, Cristina Ribeiro Cardoso, An overview of the modulatory effects of oleic acid in health and disease, PubMed, 2013 Feb;13(2):201-10. PMID: 23278117

[12] Terrestrosin D, Min Qiu a,*, Ming An a,*, Mengni Bian a, Shunbang Yu b, Changxiao Liu c, Quanli Liu aTerrestrosin D from Tribulus terrestris attenuates bleomycin-induced inflammation and suppresses fibrotic changes in the lungs of mice, PubMed, 2019 Oct 14;57(1):694–700. doi: 10.1080/13880209.2019.1672754

[13] U R Juergens 1, Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases, PubMed, 2014 Dec;64(12):638-46. doi: 10.1055/s-0034-1372609. Epub 2014 May 15.

[14] Mohan Kalaskar 1, Anjali Gavit 2, Srinivasan Prabhu 3, Manish Gagarani 4, Vinod Ugale 5, Saurabh Khadse 6, Muniappan Ayyanar 7, Sanjay Surana 8, Anilkumar Tatiya 9, Shailendra Gurav 10, Chemical composition, antioxidant, antimicrobial, and wound healing effects of Trachyspermum roxburghianum (DC.) H. Wolff essential oil: An in vivo and in silico approach, 2024 Jun 12:327:118055. doi: 10.1016/j.jep.2024.118055. Epub 2024 Mar 13.

[15] Daniel N Willis *, Boyi Liu †, Michael A Ha *, Sven-Eric Jordt †,1, John B Morris , Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants, PubMed, 2011 Dec;25(12):4434–4444. doi: 10.1096/fj.11-188383