MENOVOS TABLET

 ‘Supports WOMB HEALTH’

Menovos tablet is an Ayurvedic Proprietory medicine from Vaidyaratnam Oushadhasala used in the treatment of gynecological disorders. It balances the reproductive hormones. This formulation is a repurposing of a classical medicine,  Kanashatahwadi kashayam from Sahasrayoga( in the chapter gulma prakarana). It is a tablet with 15 ingredients  nirgundi, kumari, Shatavari, Madhuka, Mishreya, Ashoka, Kana, Sathahwa, Karanja, Cirabilvah, Daru, Bharngi, Kulatha, Tila and Rasona. 

Indications:  Secondary amenorrhea,  Anovulation, Dysmenorrhea.

Experiential wisdom :

• Scanty bleeding 
• Pre menstrual syndrome 
• Irregular or missed periods 
• Leucorrhea 
• PCOS 
• Dysmeonorrhoea and balances the reproductive hormones 

Dosage : 2 Tab before food or as directed by the physician.

Ingredients :

Each tablet prepared out of :

Cumulative Pharmacological properties of the formulation

Rasa:Thiktha katu madhura kashaya

Guna:Guru,snigdha

Virya:Samasithoshna

Cumulative Pharmacological action of the formulation

Doshakarma:Tridoshahara especially vata kaphahara

Dhathukarma:Balya,lekhana

Agnikarma:Agnidipana,pachana

Anyakarma:Yonidoshahara, udavarthanashana,vatagulmahara.

Supportive Phytoconstituents :

Phytoestrogens ( Vitex negundo) ,Flavonoids, steroids, terpenoids, proteins, phenols, carbohydrates, reducing sugar, starch, tannins, glycosides (Aloe vera),Glycyrrhizin and 18-β-glycyrrhetinic acid, Isoliquiritigenin , flavonoid (Glycyrrhiza glabra), Anethole (foeniculum vulgare), Phenolic glycoside P2 (Saraca asoca), Piperine (Piper longum) ,Carvone, limonene, trans-dihydrocarvone, α-phellandrene, myrcene, α-pinene and cis-dihydrocarvone  ,Tannin and anethol (Anethum graveolens), Enterodiol, ED; enterolactone, EL ,Phytoesterogens,Sesame seed (Sesamum indicum) .

Causes of Secondary Amenorrhea: 

• Hormonal disturbance leading to a lack of a normal menstrual cycle.
• Physical damage to the endometrium.
• Which prevents its growth, or obstruction of the outflow path of the menstrual blood.

Pharmacodynamics :

On analysing this  formula , it shows the following Pharmacological actions

Ayurvedic view:

 This formulation is predominant of thiktha katu madhura kashaya rasa, guru snigdha guna and possess samasithoshna virya. Nirgundi, Kumari, sathavari, Ashoka, Pippali, karanja, kulatha and rasona are gulmaghna. Misreya, ashoka, pippali and sathapushpa are sulahara. Pippali, sathapushpa, bharangi and tila are deepana. Kumari, sathavari and tila are balya. Asoka is having kashaya tikta rasa which helps to cure leucorrhoea. Lasuna is mentioned as pathya in vata vyadhi. It is considered as best for treating vata vikara and all types of avarana. Srothosodhana is the major action of lashuna, may help in clearance of artava vaha srotas. Ayurvedic literature, especially satapushpasatavari kalpa adhyaya of kashyapa samhitha, narrated satapushpa as an effective single drug for curing many gynaecological disorders. It is vataprashamani, which is the prime factor involved in the development of all yoni rogas in female. It shows agneyatwa , which is essential in artavajanana. Rithupravartini being the major function of satapushpa, may help in ovulation. Yonisukra visodhina (clarifies female reproductive organs and sperms/sperm fluids)  and  putrada (giver of progeny) are its specific properties, explained in relation with reproductive system. Acharya Susrutha metioned the use of kulatha in nasthartava. Kulatha pacifies vata and kapha but aggravates pitha. Tila has specific action in artavavaha srotas and garbhasaya. It is snigdha ushna, artava janaka, rasayana and dantya. It helps in artava formation by Rasa poshana. Conversion of rasa to rakta helps in artava formation. Tila has sookshma guna which helps in reaching deeper dhatus, upto sukra level.Tila also supports asthi dhatu and its upadhatu- danta. This formulation contains ingredients of kanasathahwadi kashaya along with addition of nirgundi, kumari, sathavari, madhuka, mishreya and ashoka. Kanasathahwadi kashaya is srotoshodhana, artavajanaka Due to the predominance of thiktha rasa ,  and  this formulation can be given in leucorrhoea condition with suitable adjuvants.

CONCLUSION :

• Vitex negundo, Aloe vera , Asparagus racemosus ,  foeniculum vulgare , Saraca asoca , Anethum graveolens and Sesamum indicum  in this formulation are displayed the highest estrogenic-like activity . Pongamia pinnata , Holoptelea integrifolia and Cedrus deodara  has  antiinflammatory actions  . Other supporting factors like Hepatoprotective  , Hypercholesterolemia effect  and Bioenhancer  effect are also shown by the individual ingredients of this formulation.
• Thus, Menovos tablet  can be considered as a potent medication for controlling PCOS, Dysmenorrhoea  and Hormonal irregualrities .

Bibliography

• Bista R, Ghimire A, Subedi S. Phytochemicals and antioxidant activities of Aloe Vera (Aloe barbadensis). Journal of Nutritional Science and Healthy Diet. 2020 Jun;1(1):25-36.
• Abd-Al-Sattar Sadiq Layl L. Hepatoprotective effect of Glycyrrhiza glabra L. extracts against carbon tetrachloride-induced acute liver damage in rats. Extracts Against Carbon Tetrachloride-Induced Acute Liver Damage in Rats (June 30, 2016). TJPRC: International Journal of Veterinary Science, Medicine & Research (TJPRC: IJVSMR) Vol. 2016 Jun 30;1:1-8.
• Hasan MK, Ara I, Mondal MS, Kabir Y. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. 2021 Jun 1;7(6):e07240
• Oktay M, Gülçin İ, Küfrevioğlu Öİ. Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts. LWT-Food Science and Technology. 2003 Mar 1;36(2):263-71.
• Dubey CK, Meena AK, Mishra V, Singh P, Bansode FW, Singh RK. Antioxidant and haematoprotective activity of the Saraca indica stem bark.
• Monsefi M, Ghasemi M, Bahaoddini A. The effects of Anethum graveolens L. on female reproductive system. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2006 Oct;20(10):865-8.
• Heidarifar R, Mehran N, Heidari A, Koohbor M, Mansourabad MK. Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2014 Apr;19(4):326.
• Akbari M, Javadnoori M, Siahpoosh A, Afshari P, Haghighi MH, Lake E. Comparison the Effect of Anethum graveolens and Oxytocin on Induction of Labor in Term Pregnancy: A Randomized Clinical Trial.
• Oshaghi EA, Khodadadi I, Tavilani H, Goodarzi MT. Aqueous extract of Anethum Graveolens L. has potential antioxidant and antiglycation effects. Iranian journal of medical sciences. 2016 Jul;41(4):328.
• Oyinloye BE, Ajiboye BO, Ojo OA, Nwozo SO, Kappo AP. Cardioprotective and antioxidant influence of aqueous extracts from Sesamum indicum seeds on oxidative stress induced by cadmium in wistar rats. Pharmacognosy magazine. 2016 May;12(Suppl 2):S170.
• Hasan MK, Ara I, Mondal MS, Kabir Y. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. 2021 Jun 1;7(6):e07240
• El-Saber Batiha G, Magdy Beshbishy A, G Wasef L, Elewa YH, A Al-Sagan A, El-Hack A, Mohamed E, Taha AE, M Abd-Elhakim Y, Prasad Devkota H. Chemical constituents and pharmacological activities of garlic (Allium sativum L.): A review. Nutrients. 2020 Mar;12(3):872.