DIGESTOL LIQUID

 ‘Better Schedule For Your Stomach’

Digestol  is an  Ayurvedic Proprietary Medicine from Vaidyaratnam Oushadhasala  useful in the treatment of  various gastrointestinal disorders mainly Anorexia, Indigestion, Flatulent ,dyspepsia and Gastroesophageal Reflux Disease(GERD). It is  a Syrup with 16 ingredients Hareeethaki, Amalaki, Kapitha, Visala, Lodra, Pippali, Vidangm, Elavalugam, Lasuna,Ardraka, Jambira, Sindulavana, Guda, Madhu and Sita.

Indication: Gastroesophageal Reflux Disease (GERD), Dyspepsia, Anorexia, Indigestion, Flatulent.

Dosage: Adults-20 ml twice daily after food ,Children-10 ml twice daiy after food or as directed by the physician.

Ingredients:

Each 10 ml prepared out of:

Cumulative Pharmacological properties of the formulation:

Rasa: Madhura kashaya amla katu

Guna: Snigdha

Virya: Sita ushna

Cumulative Pharmacological action of the formulation:

Doshakarma: Tridoshahara

Agnikarma: Deepana,pachana

Anyakarmma: Ruchya,vibandhaghna

Supportive Phytoconstituents :

Carbohydrates, glycosides, triterpenoids, saponins, tannins, polyphenols, proteins, amino acids and flavonoids (Terminalia chebula), Ascorbic acid, emblicanin A and emblicanin B (Emblica officinalis) , isosaponarin, isovitexin and isoorientin 3’-O-methyl ether (Citrullus colocynthis) ,Piperine (Piper longum), Phenolic glycosides; benzoyl salireposide and salireposide (Symplocos racemosa), Linoleic-acid (Prunus avium), Diallyl sulfide (DAS) and S-allyl mercaptocysteine (SAMC) (Allium sativum), Vitamin C , D-limonene ( Citrus limon).

Pharmacodynamics:

Mechanism of GERD : The mechanisms involved in the pathogenesis of GERD are multiple and include: a) motor abnormalities, such as impaired lower oesophageal sphincter (LES) resting tone, transient LES relaxations (TLESR), impaired oesophageal acid clearance and delayed gastric emptying  b) anatomical factors, such as hiatal hernia c) visceral hypersensitivity d) impaired mucosal resistance.

Modern point of view :

Ayurvedic point of view:

This formulation is predominant of  madhura kashaya amla katu rasa and snigdha guna. Hareethaki, maricha, pippali, sunti, rasona and saindhava are deepana. Maricha, pippali,  sunti  and jambeera acts as pachana. Hareethaki is anulomana. Amalaki,  sunti, jambeera and saindhava are ruchya. This formulation can be given in second phase of amlapitha due to the predominance of madhura and snigdha guna. In the first stage amapachana oushadhas with thiktha rasa is the best choice.

References:

Ayurveda:

  1. Charaka, Dridhabala. Charaka Samhita of Agnivesa with Ayurveda Dipika Commentary by Chakrapanidatta. Vaidhya Jadavji Trikamji. Varanasi; Chaukambha Prakashan; Varanasi; 2014. P.518
  2. Vagbhata Ashtanga hrudaya Ayurveda rasayana of Hemadri commentary by PL Harisadasiva sastri paradakarabhishagacharya. Chaukambha Sanskrit Sansthan; Varanasi; 2019. P.394
  3. Vagbhata Ashtanga hrudaya Ayurveda rasayana of Hemadri commentary by PL Harisadasiva sastri paradakarabhishagacharya. Chaukambha Sanskrit Sansthan; Varanasi; 2019. P.193
  4. Vagbhata Ashtanga hrudaya Ayurveda rasayana of Hemadri commentary by PL Harisadasiva sastri paradakarabhishagacharya. Chaukambha Sanskrit Sansthan; Varanasi; 2019. P.395
  5. Dr Pavana and Dr. Manoj sankaranarayanan Roganidana evum vikriti vijnana p 525-7

    Pharmacology:

    1. Tamhane MD, Thorat SP, Rege NN, Dahanukar SA. Effect of oral administration of Terminalia chebulaon gastric emptying: an experimental study. Journal of Postgraduate Medicine. 1997 Jan 1;43(1):12.
    2. Hazra B, Sarkar R, Biswas S, Mandal N. Research article Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis.
    3. Ahmed S, Naved A, Khan RA, Siddiqui S. Analgesic activities of methanol extract of Terminalia chebula fruit. Pharmacology & Pharmacy. 2015;6(12):547.
    4. Parekh J, Chanda S. Evaluation of antimicrobial activity of Terminalia chebula Retz. Fruit in different solvents. Journal of herbs, spices & medicinal plants. 2008 Jan 14;13(2):107-16.
    5. Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Archives of Toxicology. 2007 Mar;81(3):211-8.
    6. Shivaprasad HN, Kharya MD, Rana AC, Mohan S. Preliminary Immunomodulatory Activities of the Aqueous Extract of Terminalia chebula. Pharmaceutical Biology. 2006 Jan 1;44(1):32-4.
    7. Shen YC, Juan CW, Lin CS, Chen CC, Chang CL. Neuroprotective effect of Terminalia chebula extracts and ellagic acid in pc12 cells. African Journal of Traditional, Complementary and Alternative Medicines. 2017 Aug 3;14(4):22-30.
    8. Chandrasekhar Y, Phani Kumar G, Navya K, Ramya EM, Anilakumar KR. Tannins from Terminalia chebulafruits attenuates GABA antagonist-induced anxiety-like behaviour via modulation of neurotransmitters. Journal of Pharmacy and Pharmacology. 2018 Dec;70(12):1662-74.
    9. Pemminati S, Gopalakrishna HN, Shenoy AK, Sahu SS, Mishra S, Meti V, Nair V. Antidepressant activity of aqueous extract of fruits of Emblica officinalisin mice. International Journal of Applied Biology and Pharmaceutical Technology. 2010;1(2):448-54.
    10. Shukla V, Vashistha M, Singh SN. Evaluation of antioxidant profile and activity of amalaki (Emblica officinalis), spirulina and wheat grass. Indian Journal of Clinical Biochemistry. 2009 Jan;24(1):70-5.
    11. Bhavsar SK, Joshi P, Shah MB, Santani DD. Investigation into Hepatoprotective Activity of Citrus limon. Pharmaceutical Biology. 2007 ;45(4):303-11.