TILA KWATHA GRANULES

TILA KWATHA GRANULES
“On Time  On Date....”

 

A  modified form of Tila kwatha along with its additives- vyosha ,bharngi and guda mentioned in Ashtanga Hridaya -Gulma chikitsitham (A.H.Chi.14/120).

तिल क्वाथे घृत गुड व्योष भार्गी रजोऽन्वितः ॥ १२० ॥

पानं रक्तभवे गुल्मे नष्टे पुष्पे च योषितः ।

 

● User-friendly
● Palatable
● Improved shelf life.


Classical indication: Rakta gulma, Nashta pushpa in stree
Ashtavaidya Practices: Nashtarthava, Arthava kshaya.


● Regulates irregular menstruation in PCOS.
● Improves menstrual flow in scanty menstruation.
● Improves uterine and general health in normal adolescent girls following menarche.

 

Experiences reported: Management of Oligomenorrhoea, Secondary Amenorrhoea, PCOS, Osteoarthritis, Osteoporosis, Adolescent health care.


Dosage: 15 g granules twice daily before food from 5th day of menstrual cycle to next bleeding phase.


Additive- Ghee is preferred  for regulation of periods

 

Ingredients

Malayalam name

Sanskrit name

Scientific name

Ellu

Tila

Sesamum indicum

Chukku

Sunthi

Zingiber officinale

Kurumulaku

Maricha

Piper nigrum

Tippali

Pippali

Piper longum

Cheruthekk

Bharangi

Clerodendrum serratum

Sarkara

Guda

Saccharum officinarum

 

Contraindications: In Pregnancy, Chocolate cyst, Endometriosis.

 

Cumulative Pharmacological properties of Tila kwatha granules
► Rasa: Madhura, Thiktha, Kashaya
► Guna: Guru, Snigdha
► Virya: Ushna
► Vipaka: Katu
► Doshakarma:Vata kaphaharam
► Srothokarma: Srothosuddhikaram, Rasayana
► Agnikarma: Deepana
► Anyakarma: Gulmaghna, Asthidhathuvardhakam, Rakthaposhanam

Modern Pharmacological actions
► Estrogenic
► Nutritional
► Anti-inflammatory
► Antioxidant
► Hematopoietic

 




Pharmacodynamics
Ayurvedic- Tila has specific action in artavavaha srotas and garbhasaya2. It is snigdha ushna, artava janaka, rasayana and dantya2. It helps in artava formation by Rasa poshana3. Conversion of rasa to rakta helps in artava formation4. Tila has sookshma guna1 which helps in reaching deeper dhatus, upto sukra level. Agnimandya can be corrected by ingredients like vyosha and bhargi. Vyosha improves the bioavailability of tila in the srotas. Guda has specific action as padugna5. Tila is alpamootrakrit1 and grahi while guda is mootrala1 and sara and balances each other. Tila also supports asthi dhatu and its upadhatu- danta4. Effectiveness of tila kwatha granules.in Androgenic Axis, Metabolic Axis and Reproductive axis.

Androgenic Axis
Irregular periods are one of the symptoms of high DHEA because high levels of DHEA can inhibit ovulation5. Androgens oppose our other reproductive hormones, estrogen and progesterone, which are necessary for healthy ovulation.
         
Flavonoids of sesame seed stimulate and activate an enzyme known as aromatase which stimulate conversion of androgens to estrogen & progesterone, then enhances folliculogenesis7.
         
Results decrease in serum DHEA and Increase in SHBG6

Reproductive Axis
1. Estrogenic/ antiestrogenic and folliculogenisis8,9
    (due to phytoestrogen)
2. Increased Endometrial thickness
3. Decrease in size and volume of the ovary

 

Metabolic Axis

● Various studies shown that Sesamin, being an anti inflammatory agent, having potential role in the management of inflammation which is known significant factor in the pathogenesis of obesity, diabetes mellitus, and cardiovascular diseases. Sesamin exert anti inflammatory effects and impairment in insulin signaling and resistance

● The insulin resistance of PCOS results in hyperinsulinemia which, at least in part, stimulates androgen secretion by ovarian theca cells (6–8), and decreases the hepatic synthesis of sex hormone binding globulin (SHBG). If SHBG levels are too low, it can be a sign of: Hypothyroidism, a condition in which your body doesn't make enough thyroid hormones, Type 2 diabetes11.

 

   The antioxidant and anti inflammatory activity have a significant role in metabolic axis. The antioxidant activity is attributed to polyphenols and flavonoids present in the Sunti and Bharngi and also due to the presence of lignans, phytosterols and phenolic compounds present in Tila. The four components of this formulation Tila, Bharngi, Sunti and Pipalli exhibit anti inflammatory activity due to the presence of unsaturated fatty acids and lignans in Tila, piperine in Pipalli, thus regulating the  pathogenesis of obesity, diabetes mellitus, and cardiovascular diseases12,13. The bioenhancing property of Trikatu and health benefits of ghee and jaggery are added benefits.

 

Tila kwath Granules :Nutritional Values

Calorific value KJ/Kg

494.48

Carbohydrate %

69.74

Sugar %

26.7

Total Fat %

23

Saturated Fat %

14.23

Protein %

0.51

Sodium %

0.72

Pottassium %

0.02

Calcium %

0.5

 

Inferences from clinical studies conducted at Vaidyaratnam
Clinical Research was taken up at Vaidyaratnam Health centers for analyzing the effectiveness of Tila kwatha granules for a period of 3 months with ghee and without ghee.


► There are statistically highly significant results in Secondary amenorrhoea. Amenorrhea was corrected from the second month of administration of medicine as the patients started to get menstruation normally with an average interval of 28-30 days (for both the group).
► Ovulation - The 9 cases that were taken for study showed Anovulatory cycles. After a period of 3 months administration of Tila Kwatha granules, a follicular study was done where ovulation occurred between 14-18 days. This indicates that a significant result was found in anovulation with the administration of Tila Kwatha granules.
► Endometrial Thickness - There was significant result in the Endometrial thickness as the 12 patients had an average 4-5 mm thickness during the ovulatory period and did not increase till the 18th day. After administration of Tila Kwatha granules the endometrial thickness increased to an average of 7-8 mm on the 14th day of menstruation ( more prevalent in group administered with ghee).
► Size of the Ovary - There was significant change in the size and volume of ovary which was mainly due to the presence of cysts. The volume of the ovary changed from 14cc to 10cc after administration of Tila Kwatha Granules.

 

References
1. Bhavaprakasha
2. Ashtanga hrudaya utharasthana,Rasayanavidhi/sloka no 159
3. Charaka.chikitsa 15/17
4. Sarangadhara samhita purvakhandam sharira-5th chapter.
5. Rajanighantu
6. Wen-Huey Wu,*2 Yu-Ping Kang,* Nai-Hung Wang,* Hei-Jen Jou,y and Tzong-An Wang** Sesame Ingestion Affects Sex Hormones, Antioxidant Status, and Blood Lipids in Postmenopausal Women.
7. Al-kadhi NA, Abass KS, Jaafar SE. Enhancement effect of sesame seeds oil on some physiological parameters in the serum of female mice treated with tamoxifen. Eurasian Journal of Biosciences. 2020 Sep 30;14(2):3669-81.
8. Pianjing P, Thiantanawat A, Rangkadilok N, Watcharasit P, Mahidol C, Satayavivad J. Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells. Journal of agricultural and food chemistry. 2011 Jan 12;59(1):212-21.
9. Jyothi Jacob. Effect of Satapushpa churnam with tilatailam in oligomenorrhoea associated with polycystic ovarian syndrome. Government Ayurveda college, Trivandram; 2015.
10. Al-Bazii SJ, Al-Masoudi FJ, Obeid AK. Histological Effects of Sesamum Indicum Seeds on Mammary Gland tissue in Female white Rats. Materials Science and Engineering 2019 Jul 1 (Vol. 571, No. 1, p. 012057).
11. Amin F. Majdalawieh, Sarah M. Yousef, imad A Abu-yousef and Gheyath K. Narsrallah. Immunomodulatory and anti inflammatory effect of sesamin: mechanisms of action and future directions.
12. Mili A, Das S, Nandakumar K, Lobo R. A comprehensive review on Sesamum indicum L.: Botanical, ethnopharmacological, phytochemical, and pharmacological aspects. Journal of Ethnopharmacology. 2021 Dec 5;281:114503.
13. Singh MK, Khare G, Iyer SK, Sharwan G, Tripathi DK. Clerodendrum serratum: A clinical approach. Journal of Applied Pharmaceutical Science. 2012;2(2):11-5.

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